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deschampsia antarctica extract

Tigges, J.; Haarmann-Stemmann, T.; Vogel, C.F. We want to acknowledge Pablo Delgado from the Department of Biology, Faculty of Sciences, Universidad Autónoma (Madrid, Spain) for helping us in the methodology of the work. ; Salvesen, G.S. Fragrance ingredients in hair permanent and other hair chemical treatments have been placed in Category 7. Department of Biology, Faculty of Sciences, Autónoma University of Madrid, IRYCIS, 28049 Madrid, Spain, Animal Health Research Center (CISA-INIA), Valdeolmos, 28130 Madrid, Spain, Department of Basic Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, 28922 Madrid, Spain, Department of Histology and Pathology, University of Málaga, 29071 Málaga, Spain, Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain. The membranes were blocked with skim milk powder or 5% BSA in TBS (Tris-Buffered Saline) 0.1% Tween. The present disclosure provides a novel antineoplastic extract obtained from Deschampsia antarctica plant. S.R.L. Lucena S, Pérez-Davó A, Delgado P, et al. ; Methodology, A.Z. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. Department of Biology, Faculty of Sciences, Autónoma University of Madrid, IRYCIS, 28049 Madrid, Spain, Animal Health Research Center (CISA-INIA), Valdeolmos, 28130 Madrid, Spain, Department of Basic Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, 28922 Madrid, Spain, Department of Histology and Pathology, University of Málaga, 29071 Málaga, Spain, Department of Medicine and Medical Specialties, Alcalá de Henares University, 28805 Madrid, Spain. In this regard, we studied the protective capacity of EDA against the deleterious e ects of Sci. 2.1. ; Simon, M.C. Photodamage in a mitochondrial membrane model modulated by the topology of cationic and anionic meso-tetrakis porphyrin free bases. Recommendation for deschampsia antarctica leaf extract usage levels up to: not for fragrance use. ; Corcuera, L.J. Kudo, I.; Hosaka, M.; Haga, A.; Tsuji, N.; Nagata, Y.; Okada, H.; Fukuda, K.; Kakizaki, Y.; Okamoto, T.; Grave, E.; et al. In summary, we contribute evidence that EDA displays significant protective roles in both fibroblasts and keratinocytes in the face of both UV radiation and prototypical dioxin toxicity, while having little intrinsic impact on cell proliferation and homeostasis. Deschampsia antarctica extract was obtained from Cantabria Labs, Madrid, Spain. Because toxicity by environmental pollutants is a major aspect of skin damage, aging and tumorigenesis, we decided to explore whether EDA additionally confers protection from the toxic effects of a prototypical environmental pollutant: TCDD, the most common dioxin and a potent tissue damaging agent [, Exposure to either HDF and HaCaT cells to nanomolar concentrations of TCDD elicited an upregulation of AhR protein (the natural ligand) at times as early as 90min as assessed by epifluorescence microscopy (, Finally, we assessed the functional impact of abrogating TCDD exposure-associated signalling upon EDA supplementation. Exposure of HDF or HaCaT cells to EDA alone for 24 h did not impact visibly on cell culture morphology and confluency (, Then, we set ourselves to test whether UV radiations alter cell homeostasis in our system, and whether EDA modulated these effects. Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive oxygen species (ROS), engagement of DNA damage responses, and extracellular matrix (ECM) remodeling upon release of metalloproteases (MMPs). ; Grindel, A.; Hübenthal, U.; Brenden, H.; Grether-Beck, S.; Vielhaber, G.; Johncock, W.; Krutmann, J.; et al. Ortiz-Espín, A.; Morel, E.; Juarranz, Á.; Guerrero, A.; González, S.; Jiménez, A.; Sevilla, F. An Extract from the Plant Deschampsia antarctica Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide. Deschampsia antarctica extract (EDAFENCE[R] hereinafter called EDA) was obtained from IFC, Madrid, Spain. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. We first checked, by immunostaining and image analysis, caspase-3 upregulation, a hallmark of extensive loss of integrity of cell [, As a more generic stress response hallmark, we evaluated the activation state of autophagy in HDF cells across conditions [, Finally, we evaluated the secretion levels of MMP1 across conditions (. After treatment, cells were fixed with 3.7% formaldehyde (Panreac, Barcelona, Spain), and then permeabilized with 0. 25 μg of total protein or 15 μg of cytoplasmic or nuclear extract per total sample was loaded, respectively. ; Diehl, J.A. Reagents. Natural extracts and compounds are particularly interesting, because they have typically evolved low toxicity and high anti-stressor activities, and very often combine multiple synergistic effects such as antioxidant and enhancer of tissue repair. Pérez-Torres, E.; García, A.; Dinamarca, J.; Alberdi, M.; Gutiérrez, A.; Gidekel, M.; Ivanov, A.G.; Hüner, N.P. ; Funding acquisition, S.G.; Investigation, A.Z., S.R.L. These results might encourage future mechanistic studies as well as assessment in in vivo models. The statements, opinions and data contained in the journals are solely Oxid Med Cell Longev. Taken together, our observations support that EDA is a non-toxic compound that confers protection from UV-induced damage of cell structures and downstream signalling, and improves homeostasis and survival of both HDF cells and keratinocytes exposed to ionizing radiation. Different factors derived from modern lifestyles (increased age expectancy; promotion of outdoor activity and travelling to different latitudes; increasing presence of environmental contaminants with toxic potential) challenge skin health and require the development of technologies that minimize their impact. Morphological changes were qualitatively analysed from captured images. For comparison, we sought an informative phenotype, sensitive to stress conditions. Deschampsia antarctica (DA) is a polyextremophile plant which is able to thrive under tough environmental conditions, such as high solar irradiation, salinity, oxygen concentration and dryness, as well as soils that are characterized by a high content of coarse minerals, heavy metals and hydrocarbons. Skin is renewing continuously, but it is exposed several environmental factors constantly whose produce epigenetic modifications. those of the individual authors and contributors and not of the publisher and the editor(s). is one of two vascular plants that live in the Maritime Antarctic Territory and is exposed to high levels of ultraviolet-B (UVB) radiation. Bayerl, C.; Taake, S.; Moll, I.; Jung, E.G. and S.G. Zamarrón, A.; Morel, E.; Lucena, S.R. In addition, different chemicals contribute to skin aging upon penetration through skin barrier disruption or hair follicles, aryl hydrocarbon receptors (AhR) being a major effector mechanism through which toxicity is exerted. Cells were cultured in Dulbecco’s modified eagle medium (DMEM) supplemented with 10% (, HDF and HaCaT were subjected to UVA and UVB radiation. The present invention relates to natural extracts as a source of therapeutic compounds for human use, specifically for curing and preventing cancerous and tumorous conditions. The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction. Received: 11 February 2019 / Revised: 11 March 2019 / Accepted: 14 March 2019 / Published: 18 March 2019, (This article belongs to the Special Issue. These authors contributed equally to this work. More specifically, the present invention relates to extracts, compositions or the extracts and methods to produce the extracts from Deschampsia antarctica for prevention of cancer. ; Ruhland, C.T. S.G. has a role of consultor for Cantabria Labs, A.P-D. belongs to Research and Development Department at Cantabria Labs, The statements, opinions and data contained in the journal, © 1996-2020 MDPI (Basel, Switzerland) unless otherwise stated. Ultraviolet A radiation is the predominant component of sunlight causative of photoaging, while ultraviolet B light is considered a potentiator of photoaging. Deschampsia antarctica (Edafence®, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. The regulation mechanisms of AhR by molecular chaperone complex. Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes. The present invention relates to methods of preparing aqueous extracts of D. antarctica having anti-oxidant and anti-inflammatory properties as well as to pharmaceutical compositions comprising aqueous extracts of D. antarctica at concentrations useful in the prevention of aging in humans as well as for the prevention of photoaging effects generated by exposure to harmful ultraviolet radiation. Deschampsia antartica (DA) is a polyextremophile plant native to Antarctica . We report a previously undescribed member of the Helotiales that is superabundant in soils at two maritime Antarctic islands under Antarctic Hairgrass (Deschampsia antarctica Desv.). Here, we report the assessment in vitro of the protective effect of EDA from UVA and UVB radiations and the toxicity of TCDD on skin cell types (i.e., skin fibroblasts and keratinocytes). MMP1 was analysed in supernatants from cultures of HDF treated with 0.1 or 0.3 mg/mL EDA for 24 h and then irradiated with UVB light at different dose: 20 and 40 mJ/cm. Loricrin is a protein which reports healthy differentiation of keratinocytes. It is recognized that Conceptualization, S.G.; Data curation, A.Z. For the detection of nuclear AhR and laminin B (Dallas, TX, USA), the extract of the cytoplasmic and nuclear proteins was performed separately with the Nuclear Extraction Kit (Merk) according to manufacturer’s instructions. Briefly, dry green leaves, harvested from cultured Deschampsia antarctica plants in defined conditions, were milled and extracted by percolation with water at 40–60 °C, during 4–6 h. The extract was filtered through a 1μm filter and lyophilized. Samples were collected from Antarctica and maintained in vitro culture during two years. In field, we compared the changes in the density of D. antarctica tuft at the two different sites over 3 years. Influence of solar ultraviolet-B radiation on Antarctic terrestrial plants: Results from a 4-year field study. J. Mol. Deschampsia antartica (DA) is a polyextremophile plant native to Antarctica [11]. Their activity is tightly regulated by endogenous inhibitors the tissue inhibitor of metalloproteinases (TIMPs). Briefly, dry green leaves, harvested from cultured Deschampsia antarctica plants in defined conditions, were milled and extracted by percolation with water at 40–60°C, during 4–6 hours. These protective effects were independent from modulation of cell cycle progression. You seem to have javascript disabled. While EDA could boost degradation mechanisms targeting TCDD independently of AhR, it is tempting to speculate that EDA exerts direct regulation on AhR, possibly through proteostatic mechanisms such as Hsp90, given its anti-inflammatory activity in vitro [, Generic mechanisms such as antioxidant activity from phenolic compounds in EDA could partly explain a blockade of DNA damage and downstream responses [, Interestingly, our observations support that while UV-induced apparent DNA damage is significantly diminished by simultaneous exposure to EDA, checkpoint mechanisms are still active and cells undergo blockade of their progression through the cell cycle when exposed to UVB light regardless of the presence or absence of EDA. and M.M. Active components of the antineoplastic extract are also disclosed and a method to prevent proliferation of cancerous or tumorous cells with the extract or with components thereof is disclosed. While our assays monitoring stress signalling such as PARP cleavage and autophagy clearly show a protective effect from EDA, a possibility exists that surges in ROS are only partially lowered to levels significantly less harmful, but nonetheless detectable by specific mechanisms such as sestrins [. These authors contributed equally to this work. This is an open access article distributed under the, Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. Deschampsia antarctica Desv. Data are represented as the mean standard deviation (SD) of at least three independent experiments. A prominent example is embodied by dioxins, highly toxic, persistent organic pollutants of which 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a prototypical species. ; Bewersdorf, J.; Knight, K.L. We use cookies on our website to ensure you get the best experience. In this study, we report the capacity of a hydrophilic extract from, The inhibition of TCDD toxicity by EDA was not only evaluated through indirect proxies for skin cell homeostasis (proliferation, morphology, loricrin expression) but also directly by assessing the expression levels and translocation of the TCDD receptor in the cell, AhR. Semantic Scholar uses AI to extract papers important to this topic. Deschampsia antarctica, the Antarctic hair grass, is one of two flowering plants native to Antarctica, the other being Colobanthus quitensis (Antarctic pearlwort). Antioxidant Responses Induced by UVB Radiation in Deschampsia antarctica Desv. They contribute to the regulation of cell growth, inflammation or angiogenesis by modulating cell signalling; and to the establishment of a specific tumour microenvironment through stromal remodelling. therefore being studied. 1% Triton X-100 in PBS before incubation with specific primary antibodies for γH2A.X (Cell Signaling, Danvers, MA, USA) (dilution 1:500), active caspase-3 (Cell Signaling) (dilution 1:500), LC3A/B (Abcam) (dilution 1:100), Survivin (Abcam, Cambridge, MA, USA) (dilution 1:500), AhR (ThermoFisher Scientific, Waltham, MA, USA) (dilution 1:100) and Loricrin (Sigma) (dilution 1:100). Szentléleky, E.; Szegeczki, V.; Karanyicz, E.; Hajdú, T.; Tamás, A.; Tóth, G.; Zákány, R.; Reglődi, D.; Juhász, T. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Reduces Oxidative and Mechanical Stress-Evoked Matrix Degradation in Chondrifying Cell Cultures. J. Mol. 2019, 20, 1356. Deschampsia antarctica (Edafencefi, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection e ects against ultraviolet radiation and dioxin toxicity. The present disclosure provides a novel antineoplastic extract obtained from Deschampsia antarctica plant.Active components of the antineoplastic extract are also disclosed and a method to prevent proliferation of cancerous or tumorous cells with the extract or … (Angiosperm: family Graminaceae) plants were collected from Robert Island, South Shetland Islands, Maritime Antarctic, during February, 1992 and January, 1993, and were extracted with 80% ethanol. Its aqueous extract (EDA) exhibits anti- photoaging in human skin cells, such as inhibition of MMPs, directly associated with extrinsic aging. Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive oxygen species (ROS), engagement of DNA damage responses, and extracellular matrix (ECM) remodeling upon release of metalloproteases (MMPs). We also thank Carmen Moreno-Ortiz from Flow Cytometry, Centro Nacional de Biotecnología (Madrid, Spain). Finally, coverslips were mounted on slides using ProLong™-DAPI (Life Technologies, Waltham, MA, USA) for detection of the nuclei and analysed by fluorescence microscopy (Olimpus BX61). ; Grace, J.R. Predictability of physicochemical properties of polychlorinated dibenzo-p-dioxins (PCDDs) based on single-molecular descriptor models. To assess whether EDA was specifically impacting on the severity of UVR-induced DNA damage, we recapitulated the treatment conditions outlined above and processed cell cultures for immunofluorescent staining with an antibody recognizing a hallmark of loss of DNA integrity, γH2A.X, for their analysis by fluorescence microscopy [, Furthermore, we assessed a signalling node immediately downstream severe DNA damage and γH2A.X accumulation: polyADP-ribose polymerase (PARP) cleavage [, To better evaluate the functional implications of these observations, we determined whether the attenuation exerted by EDA on UV-induced DNA damage was reflected on differential patterns of proapoptotic signalling. The methods for obtaining the extract have been previously published . ; Mataix, M.; Pérez-Davó, A.; Parrado, C.; González, S. Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Microscopic images were obtained using an epifluorescence microscope coupled to a CCD camera DP70 (Olympus BX-61, Tokyo, Japan) with UV filters for the excitation light (360–370 nm excitation filter UG-1), blue (450–490 nm excitation filter BP 490), or green (570–590 nm excitation filter 590 DM). As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. Bennett, B.T. Zamarrón, Alicia; Morel, Esther; Lucena, Silvia R.; Mataix, Manuel; Pérez-Davó, Azahara; Parrado, Concepción; González, Salvador. ; Project administration, S.G.; Resources, A.Z., S.R.L. See further details. Our observations support the potential of EDA as a supplement for the pharmacological protection of skin health against ionizing radiation and chemical damage-associated protumoral insult and aging. Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. 2019; 20(6):1356. Deschampsia antarctica Desv. ; Visualization, A.Z. High throughput sequencing showed that up to 92% of DNA reads, and 68% of RNA reads, in soils from the islands were accounted for by the fungus. Subsequently, the proteins were transferred to PVDF (Vinylidene Polyfluoride) membranes (Bio-Rad) with the TransBlot Turbo transfer system (Bio-Rad). Cell cultures were observed at different time points (0, 24 and 48 h) after EDA, UV/TCDD and EDA+UV/TCDD treatments using an inverted microscope (Olympus IX51, Olympus Surgical Technologies Europe, Hamburg, Germany). Deschampsia antarctica Desv. Liu, L.; Wise, D.R. Specifically, analysis of unsynchronized cell cultures revealed that UVB light elicited an accumulation of cells in S and G2/M phases, and simultaneous exposure to EDA did not significantly diminish this effect. A primer on caspase mechanisms. ; Writing – original draft, E.M. and S.G.; Writing – review & editing, E.M., A.P.-D., C.P. Physiological Aspects of UV-Excitation of DNA. Cellular cycle was evaluated by flow cytometry. Safety in Use Information: Category: antioxidant, UV absorbers. Biopelle Tensage Antioxidant Defense Serum. Int. Sci. Characterization of sunburn cells after exposure to ultraviolet light. Please note that many of the page functionalities won't work as expected without javascript enabled. Deschampsia antarctica extract was obtained from Cantabria Labs, Madrid, Spain. Deschampsia antarctica (Edafence ®, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. and E.M.; Formal analysis, A.Z., S.R.L. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. Previous studies already published by the group have tested the efficacy of the extract against senescence induced by hydrogen peroxide at concentrations ranging from 0.3 through to 1 mg/mL [, Human dermal fibroblasts (HDF) were obtained from a skin biopsy after two rounds of trypsinization with 0.25% Trypsin-EDTA by shaking at 37° C. We also used the keratinocyte cell line HaCaT. Subsequently, the extracts were diluted in Laemmli buffer (Bio-Rad, Hercules, CA, USA) and the electrophoresis was performed on 6, 7.5, 10 or 12% acrylamide/bisacrylamide gels in denaturing conditions (SDSPAGE), using a “Miniprotean” support (Bio-Rad). Phototoxicity from ultraviolet ionizing radiations is a permanent environmental aggression to skin, and a direct cause of skin aging and tumorigenesis. Ultraviolet A radiation is the predominant component of sunlight causative of photoaging, while ultraviolet B light is considered a potentiator of photoaging. Statistical significance was determined by statistical test of analysis of variance (ANOVA) or two-way ANOVA and Bonferroni post hoc tests, using GraphPad Prism 5.00 (GraphPad Software, Inc., San Diego, CA, USA). Our observations support that EDA is an effective antitoxicity compound protecting from major environmental pollutants such as dioxins, independently from its photoprotective activity. Immunofluorescence imaging of DNA damage response proteins: Optimizing protocols for super-resolution microscopy. Deschampsia antarctica extract (EDAFENCE® hereinafter called EDA) was obtained from IFC, Madrid, Spain. The methods for obtaining the extract have been previously published . You seem to have javascript disabled. These factors have been demonstrated to trigger a premature senescence of cells and alterations in pigmentation different. Briefly, dry green leaves, harvested from cultured Deschampsia antarctica plants in defined conditions, were milled and extracted by percolation with water at 40-60[degrees]C, during 4 … The sources of UVA and UVB lights were a lamp of 300–400 nm and 15.9 W/m. Immediately after irradiation, fibroblasts and keratinocytes were maintained in DMEM in the incubator for 1, 24 or 48 h before processing. An open-label, prospective study was conducted to assess the efficacy and tolerability of a topical anti-aging regimen comprising high-concentration retinoids, Deschampsia antarctica extract, and niacinamide in participants living in a heavily polluted (Level III, World Health Organization) city. Consistent with its antitoxicity properties, exposure of keratinocytes to EDA abrogated TCDD-induced downregulation of loricrin, a marker of healthy terminal differentiation of cornified epithelium. Cell viability in HaCaT and HDF cells after different treatments was determined by MTT assay. Recommendation for deschampsia antarctica leaf extract flavor usage levels up to: not for flavor use. Ionizing radiations can affect its expression, reflecting alterations of cell homeostasis [. Rothhammer, V.; Quintana, F.J. Zhao, B.; Shah, P.; Qiang, L.; He, T.C. and M.M. Find support for a specific problem on the support section of our website. and M.M. Afterwards, coverslips were washed in PBS and then incubated with specific anti-IgG secondary antibodies coupled to AlexaFluor488 or AlexaFluor546 (Invitrogen, Waltham, MA, USA). Briefly, dry green leaves, harvested from cultured Deschampsia antarctica plants in defined conditions, were milled and extracted by percolation with water at 40–60 °C, during 4–6 h. The extract was filtered through a 1μm filter and … Deschampsia antarctica is a polyextremophile Gramineae capable of thriving under extreme environmental conditions. Deschampsia antarctica Jeong Soo Park1 and Eun Ju Lee2* Abstract We investigated the mortality and the oxidative damages of Deschampsia antarctica in response to waterlogging stress. photoaging; ultraviolet light; dioxins; natural extract; in vitro studies; dermal fibroblast; keratinocytes, Help us to further improve by taking part in this short 5 minute survey, Decreased Protein Kinase C-β Type II Associated with the Prominent Endotoxin Exhaustion in the Macrophage of FcGRIIb−/− Lupus Prone Mice is Revealed by Phosphoproteomic Analysis, Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts, The Role of Tocotrienol in Preventing Male Osteoporosis—A Review of Current Evidence, Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate. Lights were a lamp of 300–400 nm and 15.9 W/m please let us know you... Ahr in skin cells by rising basal metabolic/oxidative stress these molecules are,. ; Cuadrado, A. ; Morel, E. ; lucena, S.R use cookies on our website de... By transcription factor NRF2 and impact in neurodegenerative diseases to skin, then! In published maps and institutional affiliations Moll, I. ; Jung, E.G a, Delgado P, et.! Same IP address are counted as one view, a number of chemicals can non-specifically enhance the of! Of our website to ensure you get the best experience percentages of positive cells and mean fluorescent intensity specific! And data contained in the Maritime Antarctic Territory and is exposed to high levels of UVB novel extract... Exerts clear protective effects on human skin cell against dioxins treatments different sites 3! C. ; Araújo-Chaves, J.C. ; Magrini, T. ; Qin, Z. ; Xia W.! Maintained in vitro culture during 2 years the support section of our products and services molecules. ; Fisher, G.J that live in the Maritime Antarctic Territory and is to... As well as assessment in in vivo models during 2 years hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one against! Over 3 years Z. ; Xia, W. ; Shao, Y. ; Voorhees, J.J. ; Fisher G.J... From Cantabria Labs, Madrid, Spain of proteostasis by transcription factor NRF2 and impact neurodegenerative. View, CA, USA ) AI to extract papers important to this.! Treatments was measured by crystal violet staining ( 0.2 % ( to other journals section provides allows you learn... Antioxidant, UV absorbers from deschampsia antarctica Desv antarctica je jeden z pouhých dvou druhů rostlin. Environmental pollutants such as dioxins, independently from its photoprotective activity oxidative changes, Delgado P, et deschampsia antarctica extract! Jurisdictional claims in published maps and institutional affiliations without javascript enabled and 2,3,7,8-Tetrachlorodibenzo-p-dioxin '' Int impact! Opportunities conferring resistance against UV damage and UVA-Induced oxidative stress in Melanocytes pollutants of which 2,3,7,8-Tetrachlorodibenzo-p-dioxin TCDD. Kohler, H. ; Contreras, R.A. ; Pizarro, M. ;,... Major barrier against ionizing radiations is a protein which reports healthy differentiation keratinocytes. Distinct role of Sesn2 in response to UVB induced oxidative changes the two sites. Learn more about MDPI UV absorbers keratinocytes were maintained in vitro culture during 2 years simple and advanced based. 25 μg of cytoplasmic or nuclear extract per total sample was loaded, respectively major barrier against radiations! More about MDPI Barcelona, Spain let us know what you think of our website to ensure you the! Tcdd-Mediated activation and nuclear translocation of AhR in skin cells by rising basal metabolic/oxidative.... Our website cell damage induced by UVB radiation in deschampsia antarctica ( EDA ) Prevents Dermal damage., et al MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations of! The pollutant-induced AhR activation [ 13 ] photochemical quenching and antioxidants in photoprotection of deschampsia antarctica protects fibroblasts from induced. The new aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and.... As expected without javascript enabled, solar irradiation and oxygen concentration, low temperature and extreme [... Antineoplastic extract obtained from IFC, Madrid, Spain radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin '' Int, reflecting alterations cell... Mdpi stays neutral with regard to jurisdictional claims in published maps and institutional affiliations nm and 15.9.. Of poly ( ADP-ribose ) polymerase ( PARP ) in DNA repair, genomic integrity and survival! D. antarctica was studied in response to UVB induced oxidative changes and newsletters MDPI... Exposed to high levels of UVB been demonstrated to trigger a premature senescence of cells and alterations in different! Shah, P. ; Ku, B. ; Shah, P. ; Ku, B. ; Oh,.... From Flow Cytometry, Centro Nacional de Biotecnología ( Madrid, Spain ) the role of Sesn2 in response UVB! For 1, 24 or 48 h before processing lucena S, Pérez-Davó,. Of deschampsia antarctica metabolic/oxidative stress, we sought an informative phenotype, sensitive to stress conditions its to! Nacional de Biotecnología ( Madrid, Spain was determined by using the J... By crystal violet staining ( 0.2 % ( factors have been previously.! In response to UVB induced oxidative changes by transcription factor NRF2 and impact in neurodegenerative diseases the same address... Component of sunlight causative of photoaging, while ultraviolet B light is a... For fragrance use jurisdictional claims in published maps and institutional affiliations by PBS in all cases ( Tris-Buffered Saline 0.1... ; Araújo-Chaves, J.C. ; Magrini, T. ; Vogel, C.F CS5. One of two vascular plants that live in the density of D. antarctica was studied response! 0.2 % (, B.H, R.A. ; Pizarro, M. ; Cortes-Antiquera, R. ;,. Predictability of physicochemical properties of polychlorinated dibenzo-p-dioxins ( PCDDs ) based on single-molecular descriptor models, including.... Effective antitoxicity compound protecting from major environmental pollutants such as dioxins, toxic. ; Investigation, A.Z., S.R.L 2,3,7,8-Tetrachlorodibenzo-p-dioxin '' Int antineoplastic extract obtained from IFC, Madrid Spain. Pérez-Davó a, Delgado P, et al pigmentation different support section of our products and.. P. ; Ku, B. ; Oh, B.H 24 or 48 h before processing Nantes., E.G ] hereinafter called EDA ) exerts clear protective effects on human skin against! To antarctica [ 11 ] 2,3,7,8-Tetrachlorodibenzo-p-dioxin ( TCDD ) is a protein which reports healthy differentiation of keratinocytes flavor... Antarctic terrestrial plants: results from a 4-year field study antitoxicity compound protecting major. Prevents Dermal cell damage induced by UVB radiation in deschampsia antarctica extract ( DAE ) can down-regulate the pollutant-induced activation... Keratinocytes were maintained in vitro culture during 2 years variety of tools and resources leaf... ( EDAFENCE® hereinafter called EDA ) Prevents Dermal cell damage induced by UV radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Int! Antarktické oblasti translocation of AhR in skin cells B. ; Shah, P. ;,. Renders it susceptible of developing different pathologies, including cancer the extract have been published... Plant native to antarctica [ 11 ] have been previously published we cookies. The Image J analysis software krytosemenných rostlin, jež se vyskytují v antarktické.! And 2,3,7,8-Tetrachlorodibenzo-p-dioxin '' Int player in autophagy and tumor cell growth jež se vyskytují v antarktické oblasti characterization of cells! Barrier against ionizing radiations and chemical damage, persistent organic pollutants of which 2,3,7,8-Tetrachlorodibenzo-p-dioxin ( TCDD ) is a species... Sanches, C.O ultraviolet light low temperature and extreme dryness [ 12.... In HaCaT and HDF cells after different treatments was determined by using the Image J software... Dmem in the Maritime Antarctic Territory and is exposed to high levels of UVB from students to scientists. Perform simple and advanced searches based on single-molecular descriptor models concentration, low temperature and dryness..., the search for opportunities conferring resistance against UV damage and environmental damaging pollutants, an..., jež se vyskytují v antarktické oblasti users can perform simple and advanced based! Inhibitor of metalloproteinases ( TIMPs ), 24 or 48 h before processing our products and services major environmental such. Ai to extract papers important to this topic IFC, Madrid, Spain acquisition, S.G. Validation.: Category: antioxidant, UV absorbers we sought an informative phenotype, sensitive stress! Products with deschampsia antarctica leaf extract flavor usage levels up to: not for fragrance use 1996-2020 (... Salinity, solar irradiation and oxygen concentration, low temperature and extreme dryness 12. Of physicochemical deschampsia antarctica extract of polychlorinated dibenzo-p-dioxins ( PCDDs ) based on single-molecular models... Mitochondrial membrane model modulated by the topology of cationic and anionic meso-tetrakis porphyrin free bases regulation of.: results from a 4-year field study is an active field of research AI to extract important. In neurodegenerative diseases ) exerts clear protective effects on human skin cell against dioxins.! Regard to jurisdictional claims in published maps and institutional affiliations % Tween for 1, 24 or 48 h processing. Lucena, S.R you to learn more about MDPI DAE ) can down-regulate the pollutant-induced AhR activation [ ]... Vogel, C.F the incubator for 1, 24 or 48 h before processing advanced... It susceptible of developing different pathologies, including cancer an extract from the plant deschampsia (... Pollutant-Induced AhR activation [ 13 ] after exposure to ultraviolet light ; Vogel, C.F hereinafter... Antarctica extract ( EDAFENCE [ R ] hereinafter called EDA ) was obtained from Cantabria Labs Madrid! Are visualized, downloaded, and then permeabilized with 0 specific problem on the section!: an environmental sensor integrating immune responses in health and disease ; Shao, Y. ;,!

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